Antidepressants might raise threat of heart disease 1 class of antidepressant drugs may increase a patient’s threat of developing heart disease by 35 %, according to a report conducted by researchers from University College London and posted in the ‘European Heart Journal .’ The researchers compared cardiovascular disease risk among 15,000 citizens of Scotland who were taking either old antidepressants or antidepressants in the newer selective serotonin reuptake inhibitor family. They found that sufferers taking tricyclic antidepressants had been significantly more likely to suffer heart disease than those acquiring SSRIs, indicating that depression itself was unlikely to end up being causing the heart disease.

The results, published in The American Journal of Psychiatry, indicate that antidepressants do not significantly increase the risk of mania if they’re found in conjunction with a disposition stabiliser. The group used Swedish national registry data to recognize individuals with bipolar disorder who began antidepressant therapy following a year free from antidepressant treatment. The sample included 1117 sufferers who began on antidepressant monotherapy and 1641 who required a concurrent mood stabiliser. Patients acquiring an antidepressant as monotherapy had been 2.83 times more likely to develop mania during the first three months of treatment than these were in the equivalent three months of the preceding year where these were not taking an antidepressant.