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Azithromycin as effectual as penicillin for early-stage syphilis: Study WHAT: In a clinical trial involving HIV-bad volunteers with early-stage syphilis, researchers possess found that antibiotic supplements are as effectual as penicillin shots in healing early-stage syphilis. The scholarly research was backed by the National Institute of Allergy and Infectious Diseases, section of the National Institutes of Wellness. Edward W. Hook, III, M.D., of the University of Alabama at Birmingham, led the trial. Between 2000 and March 2007 June, HIV-negative volunteers aged 18 to 55 enrolled at eight sites in the usa and Madagascar. Volunteers were randomly designated to get either two shots of benzathine penicillin G or four tablets of the broad-spectrum antimicrobial macrolide medication azithromycin.