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E-52862, whose MOA is normally both complementary and novel compared to that of additional pain medications, could give a much-required addition to long term pain management options with, perhaps, the choice to be utilized as monotherapy, and also in conjunction with other treatment compounds, according to the kind of patient and medical indication.. BJP publishes data from ESTEVE’s E-52862 preclinical studies on pain ESTEVE announces the latest publication in the British Journal of Pharmacology of essential preclinical data that furthers knowledge of its highly potent and selective, once-daily, S1R antagonist E-52862, produced by the ESTEVE Analysis and Development group. Important data reported in the publication highlight the pharmacological activity of the selective S1R antagonist E-52862, which functions on the central anxious system in a variety of preclinical types of pain.