Burge’s team is now studying cells at various stages of differentiation to observe when different isoforms are expressed. Isoform switching also occurs in cancer cells. One such switch consists of a metabolic enzyme and plays a part in cancer cells burning large amounts of glucose and growing more rapidly. Learning more about such switches could lead to potential tumor therapies, Burge said. Until now, it has been difficult to review isoforms on a genome-wide scale due to the high cost of sequencing and specialized issues in discriminating related mRNA isoforms using microarrays. The team took mRNA samples from 10 types of tissue and five cell lines from a total of 20 people, and generated a lot more than 13 billion base pairs of sequence, the same as more than four whole individual genomes. The sequencing was carried out by researchers at biotech strong Illumina, using a new high-throughput sequencing machine..Zukowska mentioned that if validated in humans, the research could possibly be particularly applicable to men, whose bodies release more NPY during stress and who are more vunerable to heart attacks than pre-menopausal women generally. The findings also may prove helpful for individuals with mutations in the NPY gene, which happens in a few ethnic populations in as high as 9 % of individuals, and which causes nerves release a the neurotransmitter in elevated levels.