McDonald stated they carried out their initial study in neuroendocrine pancreatic tumors because the genetic mouse model of these tumors offers been studied so extensively, and then observed the effect in other tumors as well. The intent of the study was to explore a system, and there is absolutely no indication that effect will be confined to pancreatic tumors, he said.. Cabozantinib blocks VEGF and c-MET signaling in mouse model of pancreatic cancer Dual inhibition of vascular endothelial growth factor and c-MET signaling inhibited tumor invasion and metastasis in a laboratory model of pancreatic neuroendocrine cancer, according to a paper posted in Cancer Discovery, the most recent journal of the American Association for Cancer Research.Related StoriesResearch obtaining offers hope for better aspirin-like drugsEgalet to provide scientific data on SPRIX Nasal Spray at Painweek 2015DAPT Study displays dual antiplatelet therapy decreases bleeding-related mortalityAssociate Professor Shaun Jackson, from the Australian Center for Blood Illnesses at Monash, stated this brand-new class of drugs, known as PI 3-kinase inhibitors, may end up being quite crucial in treating coronary attack and stroke individuals by stopping development of the problem-causing bloodstream clots without causing extreme bleeding. Phase We trials in human being volunteers possess yielded promising outcomes also.